Sudden unexpected death in epilepsy (SUDEP) is an important cause of premature mortality in persons living with epilepsy (PWE) [1–2]. The incidence of SUDEP in children and adults is equal, approximately 1.2 per 1000-person years [3–5]. SUDEP is the leading cause of epilepsy-related deaths in children and adults with epilepsy [1–2]. Furthermore, next to stroke, SUDEP is the second leading cause of total years of potential life lost [6–7]. Although inroads have been made in our understanding of SUDEP, its pathophysiology remains unknown.
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