Intracellular calcium homeostasis and its dysregulation underlying epileptic seizures

Epilepsy is characterized by abnormal excessive synchronous discharge of brain neurons and remains one of the most common neurological disorders [1,2]. It is estimated that over 50 million people suffer from enduring predisposition of the brain to generate epileptic seizures [3,4], and approximately one-third of the patients are resistant to existing drugs [5]. Failure of seizure control usually causes cognitive and psychological impairment and can impose social and economic burdens [6]. Investigations of the mechanisms of epilepsy are urgently needed to identify novel approaches for seizure control.