Blog

Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy1, characterized by multiple intractable seizure types and frequent episodes of status epilepticus (SE). Seizures usually start in the first year of life2. DS is usually caused by dominant pathogenic variants in the Sodium voltage-gated channel alpha subunit 1 (SCN1A) gene3. Most affected individuals meet the criteria for intellectual disability and behavioral problems are common4. The incidence has been calculated to 1 per 15,500 live births in a prospective study5.