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Epilepsy is a non-commutable disease that affects around 50 million people around the world, with an average of 4-10:1000 habitants. Worldwide it is estimated that 5 million people are diagnosed each year with epilepsy [61]. Lennox-Gastaut Syndrome (LGS) is one of the most severe childhood developmental epileptic encephalopathies that typically arise by age 7 years, with peak onset between age 3 and 5 years [16, 19, 57]. This syndrome has multiple causes and an incidence of approximately two cases per 100,000 population [19].