Perampanel for the treatment of patients with myoclonic seizures in clinical practice: Evidence from the PERMIT study

Myoclonic seizures are involuntary jerks (brief muscular contractions) arising from the central nervous system, which can vary in distribution and intensity and may occur in different epilepsy syndromes, including some types of idiopathic generalised epilepsy (IGE), progressive myoclonus epilepsies and epileptic encephalopathies.[1, 2] The International League Against Epilepsy includes classifications for myoclonic seizures that are both focal and generalised in origin.[3] Some myoclonic epilepsies, including progressive myoclonus epilepsies such as Unverricht–Lundborg Disease, are among the most disabling types of epilepsy.