Hippocampal injury in patients with status epilepticus: quantitative analysis of hippocampal volume and structural co-variance network

Status epilepticus (SE) is defined as a condition resulting either from the failure of the mechanisms responsible for seizure termination or the initiation of mechanisms that lead to abnormally prolonged seizures (after time point t1). SE can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures [1]. This brain damage can be identified by MRI, mainly through signal changes in diffusion restriction imaging or hyperintensities in T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequences [2–8].

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