Depressive disorders and quality of life in patients with Psychogenic Nonepileptic Seizures and Drug Resistant Epilepsy living in Argentina

Epileptic seizures are defined as transient occurrence of signs and/or symptoms due to an abnormal excessive and hypersynchronous neuronal activity in the brain cortex [1, 2]. Epilepsy is considered as drug resistant epilepsy (DRE) when seizure freedom has not been achieved after two tolerated and appropriately chosen AEDs schedules, determined from seizures occurring within the past 12 months [3]. Approximately 30-40% of the people with epilepsy do not achieve seizure control [4,5] however only a few patients suspected of DRE are evaluated and treated at specialized epilepsy centers [5].

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