Mild encephalopathy with reversible splenial lesion: description of nine cases and review of the literature

Mild encephalopathy/encephalitis with reversible splenial lesion (MERS) is a transient clinico-radiological syndrome characterized by non-specific encephalopathy and specific magnetic resonance imaging (MRI) pattern [1]. MRI shows an ovoid lesion in the mid-splenium of the corpus callosum (SCC), with high signal intensity on diffusion-weighted sequences (DWI), decreased signal intensity on apparent diffusion coefficient (ADC) maps, high signal intensity on FLAIR (fluid-attenuated inversion recovery), and no enhancement after gadolinium infusion [1].