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Psychotropic drugs, especially antidepressants and antipsychotics, may reduce the seizure threshold and provoke epileptic seizures. In large investigations, seizure prevalence rates have been reported to range from ∼0.1 to ∼1.5% in patients treated with therapeutic doses of the most commonly used antidepressants and antipsychotics, while the incidence of the first unprovoked seizure in the general population is 0.02 to 0.06%. Based on the manufacturer’s information, the risk of seizures with selective serotonin reuptake inhibitors (SSRIs) is approximately 0.1% [1].