Seizures associated with selective serotonin reuptake inhibitors: a case of pharmacologically induced epileptic myoclonia

Psychotropic drugs, especially antidepressants and antipsychotics, may reduce the seizure threshold and provoke epileptic seizures. In large investigations, seizure prevalence rates have been reported to range from ∼0.1 to ∼1.5% in patients treated with therapeutic doses of the most commonly used antidepressants and antipsychotics, while the incidence of the first unprovoked seizure in the general population is 0.02 to 0.06%. Based on the manufacturer’s information, the risk of seizures with selective serotonin reuptake inhibitors (SSRIs) is approximately 0.1% [1].