Comparative contribution of magnetoencephalography (MEG) and single-photon emission computed tomography (SPECT) in pre-operative localization for epilepsy surgery: A prospective blinded study

Epilepsy surgery is the treatment of choice in patients with drug resistant epilepsy (DRE) which is defined as having continued seizures on maximum tolerated doses of two or more appropriately chosen antiepileptic drugs (AEDs).(1) Accurate localization of the epileptogenic zone is imperative for postoperative seizure freedom. Preoperative planning for epilepsy surgery involves analyzing seizure history, semiology, electrophysiological and neuroimaging findings. MRI reveals structural abnormalities, while single photon emission computed tomography (SPECT) detects regional cerebral perfusion during an ictal event (2).