Studies of epilepsy surveillance systems, ictal and interictal epileptiform activities (IEA) show circadian and multidien patterns, with multiday patterns of rising phase IEA suggesting seizures are more likely [1–4]. IEA are non-ictal patterns that Responsive Neurostimulation Systems (RNS) may detect via surveillance EEG, patterns could include spikes, repeated sharp waves, polyspikes and fast oscillations [3,5]. Biomarker studies might clarify how RNS evident mulitidien IEA and ictal risk are related [4,6,7].
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