Personality changes in patients with refractory epilepsy after surgical treatment: a systematic review

Epilepsy is one of the most serious and common neurological diseases, affecting approximately 50 million people worldwide [1]. Epilepsy is known to be a potentially disabling, chronic, and socially isolating condition, especially in refractory cases. As a severe disease of the central nervous system, it can influence cognitive functions, affecting attention and memory [2,3]. But does epilepsy have an impact on patients’ personality? Personality is defined as the characteristic sets of behavior, cognition, and emotional patterns that develop from biological and environmental factors and determine motivation and psychological interactions with one’s environment [4,5].