A retrospective cohort study of super-refractory status epilepticus in a tertiary neuro-ICU setting

Super-refractory status epilepticus (SRSE) is defined as status epilepticus which continues for 24 hours or more after the initiation of anaesthesia (Shorvon and Ferlisi, 2012) and includes those cases which recur upon reduction or withdrawal of anaesthetic agents. Evidence suggests that approximately 15% of all cases of status epilepticus enter super-refractoriness. Despite its high mortality, it remains poorly understood with only a few published studies on treatment and prognosis (Kantanen et al., 2017; Kantanen et al., 2015).