Somatostatin receptor expression and mTOR pathway activation in glioneuronal tumours of childhood

Glioneuronal tumours, mainly ganglioglioma (GG) and dysembryoplastic neuroepithelial tumours (DNETs), are the most frequent long-term epilepsy associated tumours (LEATs) of childhood (1). Survival rates are excellent, but most of these tumours give rise to epilepsy with focal seizures with impairment of awareness (2–6). Medication with today’s antiepileptic drugs (AEDs) may provide temporary relief, but most patients will inevitably need neurosurgery with gross total resection (GTR), which provides a high possibility of achieving long-term seizure freedom (4,7–9).

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