One of the rare joys of compiling a special edition for a Journal is being able to write a more informal prologue. On putting this collection of manuscripts together, I was reminded of a comment made to me by a rather portly, now rather famous, London nephrologist while I was a junior doctor. Over a mouthful of lunch, he told/ instructed me that there were only two things that necessitated running from the canteen. The first was a cardiac arrest, the second status epilepticus. While the concept that cardiac pathology requires immediate intervention and the type of intervention has progressively advanced over the past twenty years, the same cannot necessarily be said of status epilepticus.
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