Hypsarrhythmia is associated with widespread, asymmetric cerebral hypermetabolism

Infantile spasms is the most common epilepsy syndrome with onset in the first year of life, characterized by clusters of epileptic spasms, and often accompanied by a chaotic EEG pattern known as hypsarrhythmia 1. Prompt and effective treatment is essential in preventing the severe neurodevelopmental sequela that frequently accompany infantile spasms 2. There is broad consensus that successful response to any therapy in the treatment of infantile spasms requires resolution of both spasms and hypsarrhythmia 3.

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