Factors predicting uncontrolled seizures in epilepsy with auditory features

Epilepsy with auditory features (EAF) is a heterogeneous clinico-molecular syndrome, with or without bilateral tonic-clonic seizures, featured by seizures with auditory symptoms suggesting lateral temporal-lobe origin [1,2]. The aetiology underlying EAF is considered to be associated with specific genes because autosomal-dominant EAF has been reported extensively, and mutations mainly in the leucine-rich glioma-inactivated protein 1 (LGI1) gene were detected [3,4]. About 50% of autosomal-dominant EAF families and <2% of sporadic cases have LGI1 gene mutations [5].