Effects Of Antiepileptic Drugs On Dynamic Thiol/Disulphide Homeostasis In Children With Idiopathic Epilepsy

Epilepsy is a common chronic, neurological disorder and childhood epilepsies represent about 25% of the whole epilepsy population [1]. Modern advances in diagnostic technology, particularly in neuroimaging and molecular genetics, now permit better understanding of the pathophysiology of epilepsy. Defective ion transportor ion channel structure in the neuronal membrane, inhibitory–excitatory mechanisms, and regulatory modulator systems have been implicated in the pathogenesis of epilepsy [2–4]. Nowadays, increasing evidence suggest that oxidative stress is implicated in the underlying mechanism of epilepsy.