Seizures as a Clinical Manifestation in Somatic Autoimmune Disorders

Epilepsy is a common neurological condition with marked psychiatric and systemic comorbidity. Recent evidence suggests that systemic auto-immune disorders are often co-morbid with epilepsy [1]. A meta-analysis reported an almost 3-fold increased risk of epilepsy [odds ratio (OR): 2.66, 95% confidence interval (CI): 1.88-3.76] in people with such disorders [2]. Acute symptomatic as well as unprovoked seizures have been reported in people with autoimmune disorders. Most seizures reported are either convulsions or focal in nature [3–7].

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