Progesterone, 5a-Dihydropogesterone and Allopregnanolone’s Effects on Seizures: A Review of Animal and Clinical Studies

Epilepsy, characterized by spontaneous and recurrent seizures, currently affects 1% of the world population [1]. Despite many available therapeutic options, 1/3 of patients do not achieve seizure control [2]. Thus, searching for new and effective anti-epileptic drugs remains a central theme of epilepsy research. Among the many different candidates for drug development, the progesterone family emerges as a potential therapeutic option.