Factors associated with refractoriness and outcome in an adult status epilepticus cohort

Status epilepticus (SE) is a neurological emergency that is estimated to affect 10-16/100000 per year in Europe [1–3] with a reported mortality rate that varies between 11-37% [4–7]. It has recently been redefined by the International League Against Epilepsy (ILAE) as “a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms which lead to abnormally prolonged seizures (after time point t1). SE is a condition that can have long term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures”[8].

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