Electroclinical features of seizures associated with autoimmune encephalitis

Seizures are commonly seen in autoimmune encephalitis [1], a heterogeneous group of conditions associated with neural autoantibodies that frequently targets the cell surface and results in channelopathies, hyperexcitability and potential epileptogenicity [2,3]. A high prevalence of neural autoantibodies has been noted in focal epilepsies, with or without classic features of encephalitis ([4–6], [7]). These advances are noteworthy given targeted immunotherapeutic implications [8] and have been reflected in the most recent ILAE classification, with “immune etiology” listed alongside other classical epilepsy etiologies [9].