Epilepsia. Official Journal of the International League Against Epilepsy

Abstract

Objective

With the advent of ultra-long-term recordings for monitoring of epilepsies, the interpretation of results of isolated EEG recordings covering only selected brain regions attracts considerable interest. In this context, the question arises whether detected ictal EEG patterns correspond to clinically manifest seizures or rather to purely electrographic events, i.e. subclinical events.

Methods

The analysis of EEG patterns from 268 clinical seizures and 252 subclinical electrographic events from 50 patients undergoing video-EEG monitoring. Features extracted included predominant frequency band, duration, association with rhythmic ...

Abstract

Objective

Many early-onset epilepsies present as Developmental and Epileptic Encephalopathy associating refractory seizures, altered psychomotor development and disorganized interictal cortical activity. Abnormal upregulation of specific NMDA receptor subunits is being disentangled as one of the mechanisms of severe early-onset epilepsies. In Tuberous sclerosis complex, upregulation of the GluN2C subunit of the NMDA receptor with slow deactivation kinetic results in increased neuronal excitation and synchronization.

Methods

Starting from an available GluN2C/D antagonist, NMDA receptor modulating compounds were developed and screened using a patch clamp ...

Abstract

Objective

This study was undertaken to validate the accuracy of the Epidemiology-Based Mortality Score in Status Epilepticus (EMSE) in predicting the risk of death at 30 days in a large cohort of patients with status epilepticus (SE) using a machine learning system.

Methods

We included consecutive patients with SE admitted from 2013 to 2021 at Modena Academic Hospital. A decision tree analysis was performed using the 30-day mortality as a dependent variable and the EMSE predictors as input variables. We evaluated the accuracy of ...

Abstract

Several instruments and outcomes measures have been reported in pediatric patients undergoing epilepsy surgery. The objective of this systematic review is to summarize, evaluate, and quantify outcome metrics for the surgical treatment of pediatric epilepsy that address seizure frequency, neuropsychological, and health-related quality of life (HRQL). We performed a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify publications between 2010 and June 2021 from PubMed, Embase, and the Cochrane Database of Systematic Reviews ...

Abstract

The COVID-19 pandemic led to the development and emergency approval of an array of effective vaccines against SARS-CoV-2. Given the relatively small number of patients included in vaccine trials, postapproval epidemiological surveillance is crucial to detect infrequent vaccine-related adverse events. We conducted a nationwide retrospective descriptive study evaluating the incidence of seizures among recipients of SARS-CoV-2 vaccines in Mexico from December 24, 2020 (date of administration of first doses nationwide) to October 29, 2021. Among 81 916 351 doses of any vaccine ...

Abstract

We report on an 8-year-old girl with severe developmental and epileptic encephalopathy due to the compound heterozygous null variants p.(Gln661*) and p.(Leu830Profs*2) in GRIN2A resulting in a knockout of the human GluN2A subunit of the N-methyl-D-aspartate receptor. Both parents had less severe GRIN2A-related phenotypes and were heterozygous carriers of the respective null variant. Functional investigations of both variants suggested a loss-of-function effect. This is the first description of an autosomal recessive, bi-allelic type of GRIN2A-related disorder. Still, there are marked ...

Abstract

Objective

Lacosamide is being increasingly prescribed to pregnant women, although its effects on the developing fetus have not yet been fully clarified. Previously, we have shown that several antiseizure medications, particularly valproate, can affect the expression of carriers for essential compounds in placental cells. Here, our aim was to assess the effect of short ex vivo exposure of human placentas to lacosamide on the expression of carriers for essential nutrients required by the human fetus.

Methods

Placentas were obtained from cesarean deliveries of ...

Abstract

Objective

Intermittent rescue therapy may be used for seizure clusters, which are clinical emergencies that may persist ≥24 h and increase risk of status epilepticus, emergency room visits, and reduced quality of life for patients with epilepsy. Beyond effectiveness for aborting seizure clusters, no data exist on how intermittent rescue therapy may impact the long-term natural course of seizure clusters. This novel analysis explores SEIzure interVAL (SEIVAL; time between seizure clusters) in patients from a long-term safety study of diazepam nasal spray ...