Cognitive disorders in epilepsy II: Clinical targets, indications and selection of test instruments

The intellectual function of patients with epilepsy has been a subject of interest for centuries [1,2]. It was long thought that all patients with epilepsy have poor cognition and progressively worsening memory. This belief started to change in 1985 with the results of a prospective, double-blind, placebo-controlled study done by Mattson et al. through the Veteran’s Administration [3]. Six hundred twenty-two patients were enrolled, followed over one to six years, and given extensive neuropsychological tests before initiation of antiseizure medications ...

Seguir leyendo →
0

Seizures in autoimmune encephalitis: Findings from an EEG pooled analysis

Autoimmune encephalitis (AEs) encompasses a variable spectrum of clinical manifestations pointing to a widespread brain involvement, well beyond the limbic system alone [1]. Besides mental status alterations, cognitive deficits and behavioral/psychiatric disorders, seizures are part of the clinical core of AE [2], and often represent the most alarming and impressive sign at the disease onset, leading the patients to seek medical advice. The subacute onset of seizures, especially in elderly subjects, urges the need to investigate (and eventually rule out) ...

Seguir leyendo →
0

Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study

Hypoxic ischemic encephalopathy (HIE) occurs in 1–8 newborns per 1000 live births and it is the most common cause of seizures in term neonates. [1] Many studies in asphyxiated neonates before the advent of therapeutic hypothermia [TH] have shown a relationship between clinical and/or electrographic seizures, especially status epilepticus, and abnormal outcome. [2] Due to the overlapping between the ischemic hypoxic damage and the injury resulting from seizures activity, it is still difficult to establish the impact of seizures in ...

Seguir leyendo →
0

Pharmacokinetics, tolerability, and clinical effectiveness of perampanel in combination therapy for epilepsy with epilepsy

The novel antiepileptic drug (AED) perampanel is used in monotherapy and as an adjunctive treatment for focal, focal to bilateral, and generalized tonic-clonic seizures in patients with epilepsy. Perampanel has a high protein-binding ratio (> 95 %) and long half-life (∼105 h) and is mainly metabolized by cytochrome P450 (CYP) 3A4 [1]. Thus, it is highly susceptible to interactions with CYP-inducing AEDs (inducers), such as phenytoin (PHT), carbamazepine (CBZ), and phenobarbital (PB). In contrast, stiripentol is a strong inhibitor of CYP3A4, ...

Seguir leyendo →
0

THE PRESENTING SYMPTOMS OF LAFORA DISEASE: AN ELECTROCLINICAL AND GENETIC STUDY IN FIVE APULIAN (SOUTHERN ITALY) FAMILIES

Lafora Disease (LD, OMIM# 254780) is a progressive myoclonic epilepsy inherited in an autosomal recessive manner, due to rare mutations in either the EPM2A or the NHLRC1 genes, encoding for the laforin glycogen phosphatase on chromosome 6q24 and the malin ubiquitin E3 ligase on chromosome 6p22.3 [1], respectively. The absence of either of the two proteins results in Lafora bodies, which contain polyglucosan, a poorly branched form of glycogen, in neurons, muscle and other tissues, and main drivers of neurodegeneration ...

Seguir leyendo →
0

Epilepsy with eyelid myoclonias and Sotos syndrome features in a patient with compound heterozygous missense variants in APC2 gene

Epilepsy with eyelid myoclonias, originally depicted by Jeavons in 1977, is a reflex epilepsy characterized by jerking of the eyelids with or without absences precipitated by eye closure or by light (eyelid myoclonia, EM), eye closure-induced EEG paroxysms and photosensitivity. Childhood-onset, female predominance and a normal development are typical features, though a mild intellectual disability has been reported. Sotos syndrome is a disorder characterized by a distinctive facial appearance, learning disability and overgrowth in childhood with macrocephaly, caused by heterozygous ...

Seguir leyendo →
0

Cognitive Disorders in Epilepsy – Part II: Clinical Targets, Indications and Selection of Test Instruments

The intellectual function of patients with epilepsy has been a subject of interest for centuries [1,2]. It was long thought that all patients with epilepsy have poor cognition and progressively worsening memory. This belief started to change in 1985 with the results of a prospective, double-blind, placebo-controlled study done by Mattson et al through the Veteran’s Administration [3]. Six hundred twenty-two patients were enrolled, followed over one to six years, and given extensive neuropsychological tests before initiation of antiseizure medications ...

Seguir leyendo →
0
Página 77 de 179 «...5060707576777879...»