Seizure

The ongoing global Coronavirus Disease (COVID-19) pandemic, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected the health care including neurologic care world over. [1,2] In addition to the direct affection of nervous system by the SARS-CoV-2, the COVID-19 pandemic may have indirect impact on patients with non-COVID-19 diseases [3]. This indirect impact mainly results from the reluctance of the patients with non-COVID diseases to seek medical care because of the fear of contacting COVID-19 infection ...

Epilepsy is one of the most serious and common neurological diseases, affecting approximately 50 million people worldwide [1]. Epilepsy is known to be a potentially disabling, chronic, and socially isolating condition, especially in refractory cases. As a severe disease of the central nervous system, it can influence cognitive functions, affecting attention and memory [2,3]. But does epilepsy have an impact on patients’ personality? Personality is defined as the characteristic sets of behavior, cognition, and emotional patterns that develop from biological ...

Dravet syndrome was first described in 1978 as a rare form of epilepsy that generally presents in the first year of life [1]. While Dravet syndrome is often characterized as a seizure disorder, it is a multi-faceted early life developmental and epileptic encephalopathy (DEE) that impacts many areas of functioning. There are few systematic investigations that characterize these other features of Dravet syndrome.

The authors would like to inform you that Dr Mohammad Mansouri was omitted from the authorship of this article in error.

Super-refractory status epilepticus (SRSE) is defined as status epilepticus which continues for 24 hours or more after the initiation of anaesthesia (Shorvon and Ferlisi, 2012) and includes those cases which recur upon reduction or withdrawal of anaesthetic agents. Evidence suggests that approximately 15% of all cases of status epilepticus enter super-refractoriness. Despite its high mortality, it remains poorly understood with only a few published studies on treatment and prognosis (Kantanen et al., 2017; Kantanen et al., 2015).

We report our experience with topiramate rectal suspensions in a single center case series of three patients <1 year of age from 2017 to 2020 who received topiramate per rectum after being placed nil per os (NPO) status at a free standing children’s hospital. The objective was to describe the compounding methods and clinical outcomes of three of the youngest patients to receive topiramate rectal suspensions. All three patients received topiramate per rectum for 2–4 days. No adverse effects or increase ...

The epilepsy specialist nurse (ESN) role was first created and described in the United Kingdom in 1988 (1), and has evolved since then. There is still a lack of clarity about the functions that constitute the role of an ESN (2,3), however, ESNs have a complex and multifaceted role as they operate in a range of settings, collaborate with different professional groups, and assist both patients and carers (4–6). The ESN has been described as “an expert and essential part ...

Epilepsy with auditory features (EAF) is a focal epilepsy characterized by seizures with auditory symptoms or aphasia, suggesting a lateral temporal lobe involvement [1,2]. The onset of epilepsy is in the second/third decades of life in patients with a normal neurological status, usually negative conventional magnetic resonance imaging (MRI) and initially good drug response. Overall, the long-term outcome is not benign, with only 34.1% of patients achieving terminal remission after a median 11-year follow-up [2].

For decades, there has been a tendency to ignore the insular lobe, and to regard each hemisphere as composed of only four lobes: frontal, temporal, parietal and occipital [1]. However, it is clear that epileptic seizures can originate in the insula. Because the insula is widely connected, it can be challenging to identify the precise origin of insular seizures clinically. Most sensations that could be attributable to insular discharges could have originated in several cortical structures around the operculum connected ...