Association between epilepsy and systemic autoimmune diseases: A meta-analysis

Systemic autoimmune diseases (SAD) have gained notoriety as being a risk factor for epilepsy. Conversely, recent studies have reported that epilepsy increases the risk of systemic autoimmune diseases [1,2]. Based on the emerging data, one may speculate that there is an underlying biological mechanism, such as pro-inflammatory conditions and antibodies, which links epilepsy and SAD [2,3]. Numerous studies have focused on clarifying this association, as it could help elucidate the different roles of auto-Abs and inflammation in epileptogenesis.

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Response to “Response to Zhang et al: Levetiracetam vs. brivaracetam for adults with refractory focal seizures: A meta-analysis and indirect comparison”

We read with the interest the letter to the editor submitted by Simon Borghs and his colleagues about their methodological concerns about our work and their disagreement with our conclusions [1]. We always welcome different points of view. However, we would like to stress two points. Firstly, as stated in our paper, our work was conducted in strict accordance with Cochrane Review Methods (www.cochrane-handbook.org) and the PRISMA statement (preferred reporting items for systematic reviews and meta-analyses) [1,2].

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Response to Zhang et al.: Levetiracetam vs. brivaracetam for adults with refractory focal seizures: A meta-analysis and indirect comparison

We read with interest the meta-analysis and indirect comparison of levetiracetam and brivaracetam recently presented by Zhang et al. (Seizure 2016;39:28–33) [1]. We would like to raise two points in response. Firstly, some methodological elements common to indirect comparisons have not been addressed in the published work. Secondly, the use of network meta-analyses of clinical trials to produce valid evidence of the comparative efficacy and safety of antiepileptic drugs (AEDs) has previously been called into question, which was not discussed ...

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The burden of headache in people with epilepsy

Epilepsy is defined as a brain disorder characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition [1]. Approximately 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally [2]. One of the most useful methods to measure overall burden of a disease is the Disability-adjusted life years (DALYs); these are higher for epilepsy than for Alzheimer’s disease, Parkinson’s disease and multiple sclerosis ...

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