Microglial positron emission tomography (PET) imaging in epilepsy: applications, opportunities and pitfalls

Neuroinflammation is increasingly implicated in epileptogenesis and epilepsy. Microglia are an important mediator of central nervous system inflammation, and the development of positron emission tomography (PET) radioligands which bind the Translocator Protein (TSPO), an outer mitochondrial membrane protein expressed by microglia, has enabled in vivo measurement of neuroinflammation. Here, we outline the principles and potential pitfalls of TSPO PET imaging in relation to epilepsy, and opportunities for using TSPO imaging as a biomarker for future anti-inflammatory based therapeutics in epilepsy.

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Diagnosing and treating depression in epilepsy

Mood is determined by the predominance for specific emotions, however, it is also related to cognitive mind-sets, behavioral predispositions and states of autonomic nervous control [1]. Mood exerts a strong impact on a person’s ability to cope with different environmental conditions. Mood is strikingly stable in most people and occasional phases of variation typically recede within a small number of hours.

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Diagnosing and treating depression in epilepsy

Mood is determined by the predominance for specific emotions, however, it is also related to cognitive mind-sets, behavioral predispositions and states of autonomic nervous control [1]. Mood exerts a strong impact on a person’s ability to cope with different environmental conditions. Mood is strikingly stable in most people and occasional phases of variation typically recede within a small number of hours.

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