Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes

Juvenile myoclonic epilepsy (JME) is a generalized genetic epilepsy (GGE) syndrome, clinically characterized by irregular jerks mainly of shoulders and arms after awakening, with peak of onset between 12 and 18 years, and electroencephalographically by bilateral and synchronous 4–6/s spike and wave complexes, often in the form of polyspike and waves [1]. The main seizure type is myoclonia occurring on awakening, i.e., within 2h, present in all cases. Around 90% of JME patients have generalized tonic-clonic seizures (GTCS) and 30% ...

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